In setting the boundaries of the REFLOW Collaborative Governance framework, our reflections have been rotating around the concept of infrastructuring, understood as ‘the socio-technical scaffolding around which organizational and personal collaborative networks and relationships are built, including the ways of working, structures, artifacts, activities and attitudes that contribute to creating a supportive framework for both present and future collaboration’ (Thorpe and Manzini 2018). This concept is particularly useful as it may help frame and design collaborative governance arrangements that, while coordinating and organizing actors, assets and resources around pre-identified goals and paths of change, leaves the space open to new initiatives and projects to emerge and feeding into the system over time. In other terms, our interpretative lens of collaborative governance goes towards the definition of a loose coordination framework that organizes collaboration across three main dimensions or layers of infrastructuring - strategic, operational and relational -, these interacting continuously with each other and contributing to forming the actual shape of the social, cultural and economic fabric of the city. When it comes to creating a circular and regenerative city, this framework can help organize, activate and coordinate not only those key resources that are deemed essential to kickstart the transition - and which might be articulated via a more top-down approach led by Municipalities -, but it can rather account for the constellation of all those projects - often citizens-led and bottom-up - that can meaningfully contribute to the transition itself. Therefore, this framework largely looks at collaborative governance as a means for inclusive and participatory circular economy in urban contexts, leveraging all assets and strengths that may exist in cities. Moreover, the framework attempts to take into account the processual dimension of urban governance, concentrating not only on how the three layers entrench and mutually reinforce each other, but also depicting an open-ended design process that embeds learning by doing as a means to improve scale and scope of collaboration over time.